What makes I-Endran special?

• After the patent expiration, various PN ingredient skin boosters have been introduced. I-Endran has a sufficient PN content and is composed of pure PN extracted from salmon. It can be a suitable choice for those who want consistent eye area care at a reasonable price. When undergoing the procedure, it is advisable to check if salmon-derived PN raw materials are used.
• Treatment is possible not only under the eyes but also on the eyelids and the delicate areas around the eyes. The depth of the skin layer is adjusted according to the desired area, and the 'embo' (papule) procedure is performed.
• A precise amount of 2cc of PN ingredient is used, injected as the undiluted solution without saline dilution.
• Its low viscosity can result in less pain during the procedure, and the 'embo' (papule) phenomenon also tends to subside relatively quickly.
• Designed specifically for the eye area, it can be comfortably applied to sensitive areas without burden.
• Since discomfort during the procedure is relatively low, full-face treatment, in addition to the eye area, can also be considered. It can help improve facial dullness, inner dryness, and fine lines.
• Based on expertise in acupuncture and injection procedures, it is possible to precisely inject PN into the dermal layer. After the procedure, we will check the 'embo' (papule) phenomenon around the eyes with the patient.

What is I-Endran (PN) Skin Booster?

I-Endran is a skin booster containing PN (Polynucleotide) ingredients, developed considering the unique characteristics of the skin around the eyes.

This procedure is designed to help improve fine lines, dark circles, and inner dryness around the eyes.

I-Endran is a PN ingredient specifically designed for the thin skin around the eyes. Its formulation is softly designed for comfortable injection into the eye area, and it can feature relatively less pain during the procedure and reduced 'embo' (papule) phenomenon.

Eye Area Skin: Why does it need I-Endran?

The skin around the eyes is the thinnest and most sensitive area on the entire face.

Due to these characteristics, it is vulnerable to external stimuli, and changes due to aging or dryness can appear relatively quickly.

The skin barrier can easily weaken, making inner dryness, fine lines, and bluish dark circles common occurrences.

However, due to its structure, the eye area has less subcutaneous fat and a thin dermal layer itself, meaning that regular moisturizers or eye creams alone may have limitations.

Therefore, a method of directly injecting PN ingredients into the dermal layer to aid skin regeneration can be usefully considered for eye area improvement.

What is PN (Polynucleotide)?

PN (Polynucleotide) is a high-purity biomaterial obtained from salmon DNA.

Compared to PDRN, it has a larger molecular weight and is known as an ingredient that can induce reactions in the dermal layer and help with its sustainability.

Simply put, if PDRN supports basic moisturizing and regeneration processes, PN can directly stimulate the dermal layer to contribute to improving skin structure.

PN can primarily help improve skin through the following processes:

It stimulates fibroblasts to help produce collagen and elastin. This can contribute to giving skin elasticity, gently alleviating fine wrinkles, and improving skin texture.

It promotes the secretion of growth factors like TGF, FGF, and VEGF to aid the skin's recovery process. It can support the regeneration of damaged tissues and soothe inflammatory reactions, helping the skin maintain a healthy state.

It can induce epidermal cell regeneration and strengthen skin barrier function. By strengthening the bonds between keratinocytes, it can reduce moisture loss and contribute to improving inner dryness.

Skin is composed of a barrier structure where keratinocytes can be compared to bricks and intercellular lipids to cement.

PN can strengthen the role of these intercellular lipids to prevent moisture evaporation and help improve inner dryness and skin sensitivity.

It can help repair damaged dermal tissue and contribute to increasing dermal thickness. This can help alleviate dark circles caused by thinned dermis and improve fine lines.

Skin has a barrier structure where keratinocytes and intercellular lipids are combined like bricks and cement. PN can help restore this barrier and reduce moisture loss, contributing to improving both inner dryness and skin sensitivity.

The Meaning of the 'Embo' Phenomenon and Dermal Layer Injection

Due to its structure, the dermal layer has a relatively narrow internal space.

Therefore, when medication is injected during the procedure, the skin often temporarily swells.

This phenomenon is called the 'embo' (papule) phenomenon, and it can be seen as a sign that the medication has been well delivered to the target dermal layer.

After the procedure, we will check and explain the 'embo' (papule) phenomenon with the patient.

I-Endran has a thin viscosity, so the 'embo' (papule) phenomenon usually subsides relatively quickly within 1 week. Discomfort felt during the procedure is also relatively low, allowing for more comfortable consideration of treatment even in sensitive and thin areas like the eyes.

Consider this treatment if:

• You are starting to notice fine lines around your eyes.
• You are concerned about bluish dark circles. The bluish appearance around the eyes is due to the thin dermal layer allowing blood vessels to show through, and I-Endran can contribute to alleviating dark circles by inducing a subtle increase in dermal thickness.
• You experience inner dryness, leading to makeup not adhering well and a rough skin texture.
• This treatment is for those who hesitate to get lifting procedures due to sensitive or thin skin.
• Those who found it difficult to achieve desired eye area improvement with existing eye creams alone may also consider this.
• It is suitable for those who are concerned about fine wrinkles on their eyelids but have been told that treatment is not easy due to the delicate area.
• It is also a good option for those who want to improve fine wrinkles in the area immediately next to the eyes.

Recommended Treatment Interval and Duration Guide

• Generally, we recommend three treatments, once a month.
• After that, touch-up treatments approximately every 6 months can help maintain the effect.
• The duration of the effect is expected to be approximately 6 months to 1 year, but individual differences may occur.
• We strive to minimize pain during the procedure. Any post-treatment swelling usually subsides naturally within 1 to 3 days.

Director's Treatment Philosophy

We believe that eye area treatments are not merely about improving visible wrinkles, but more importantly, about activating the skin's inherent regenerative and self-healing capabilities.

When consistent eye cream use feels insufficient, eye endran treatments can help with skin changes.

There may come a point when satisfactory improvement is difficult to achieve with superficial skincare alone.

At this time, an approach that improves the fundamental aspects within the skin is necessary. Treatments that healthily restore the density or thickness of the dermal layer fall under this approach.

Eye Endran is one such treatment that can be the starting point for such fundamental skin improvement.

If there is a genuine desire to care for the skin, then the practitioner's touch must also be equally delicate and dedicated.

All processes are important: injecting the medication into the precise area, meticulously monitoring the treatment process, and closely observing the patient's progress.

Our medical team will approach patients with such a careful and professional approach.